Localized multiple pseudoatrophic plaques: a rare clinical form of segmental neurofibromatosis.

Sir, Segmental neurofibromatosis (NF) is characterized by multiple neurofibromas or café-au-lait spots (1–4). It is unclear whether segmental NF is arranged within dermatomes or not. This disorder is considered to arise from a post-zygotic NF-1 gene mutation resulting in somatic mosaicism (5). We report here a case of segmental NF, in which multiple neurofibromas showed an unusual clinical presentation in the form of localized multiple pseudoatrophic plaques. The lesion histopathologically showed neoplastic proliferation in a dispersed pattern within the middle reticular dermis associated with only a small amount of collagenous stroma.